| Position(s) |
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| Office Phone | 515-271-1528 | ||
| Fax | 515-271-7128 | ||
| martin.schmidt@dmu.edu | |||
| Education |
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| Areas of Expertise |
Dr. Schmidt’s laboratory is currently examining the effects of a common broad-spectrum poison, boric acid, on the metabolism and cell biology of yeasts. The observations of both the model yeast Saccharomyces cerevisiae and the pathogenic yeast Candida albicans aim at understanding boric acid’s mechanism of action and its suitability for alternative antifungal therapy. Dr. Schmidt also continues his work on the cell biology of S. cerevisiae that aims at a molecular understanding of cell wall synthesis and morphogenesis.
Publications
Pointer B, Boyer MP and Schmidt M. Boric acid destabilizes the hyphal cytoskeleton and inhibits invasive growth of Candida albicans. Yeast, in press., 2015
Schmidt M, Akasaka K, Messerly JT and Boyer MP. Role of Hog1, Tps1 and Sod1 in boric acid tolerance of Saccharomyces cerevisiae. Microbiology 158, 2667-2678., 2012
Schmidt M, Schaumberg JZ, Steen CM and Boyer M. Boric acid disturbs cell wall synthesis in Saccharomyces cerevisiae. Int. J. Microbiol. Vol. 2010, Article ID 930465, 2010
Schmidt M, Dzogbeta S and Boyer MP. Inhibition of Candida albicans by fluvastatin is dependent on pH. Res. Lett. Biochem. vol. 2009, Article ID 151424., 2009
DeSeta F, Schmidt M, Vu B, Essmann M and Larsen B. Antifungal mechanisms supporting boric acid therapy in Candida vaginitis. J. Antimicrob. Ther. 63(2):325-336. Epub 2008 Dec 4., 2009
Schmidt M, Barker S, Essmann M and Larsen B. Effects of commonly used herbicides on the virulence factor CDR1 in Candida albicans. Environ. Toxicol. 27(11), 2346-2351., 2008
Schmidt M, Drgon T, Bowers B and Cabib E. Hyperpolarized growth of Saccharomyces cerevisiae cakP212S and cla4 mutants weakens cell walls and renders cells dependent on chitin synthase 3. FEMS Yeast Res 8(3), 362-373., 2008
Larsen B, Andersen S, Brockman A, Essmann M and Schmidt M. Key Physiological Differences in Candida albicans CDR1 Induction by Steroid Hormones and Antifungal Drugs. Yeast 23, 795-802., 2006
Schmidt M, Strenk ME, Boyer MP and Fritsch B. Importance of cell wall mannoproteins for septum formation in Saccharomyces cerevisiae. Yeast 22(9), 715-723., 2005
Schmidt M. Survival and cytokinesis of Saccharomyces cerevisiae in the absence of chitin. Microbiology 150(10), 3253-360., 2004