Dr. Schmidt has focused his attention on the storage of metabolic energy in simple eukaryotes. The yeasts Saccharomyces cerevisiae and Candida albicans store metabolic energy in the form of glycogen (carbohydrates) and triglycerides (fat). But even though the yeasts commit considerable resources to building glycogen and triglyceride stores, ablation of their synthesis has no negative impact on growth and survival of prolonged starvation. Current work aims at probing the connections between the storage mechanisms, the flow of metabolites from carbohydrate to lipid metabolism and the characterization of mutants with multiple defects in macronutrient shortage.
Following his appointment as a curriculum fellow in 2018, Dr. Schmidt has also begun educational research on the effect of curricular interventions on learning outcomes.
Schmidt M, Akasaka K, Messerly JT and Boyer MP. Role of Hog1, Tps1 and Sod1 in boric acid tolerance of Saccharomyces cerevisiae. Microbiology 158, 2667-2678., 2012
Schmidt M, Schaumberg JZ, Steen CM and Boyer M. Boric acid disturbs cell wall synthesis in Saccharomyces cerevisiae. Int. J. Microbiol. Vol. 2010, Article ID 930465, 2010
Schmidt M, Dzogbeta S and Boyer MP. Inhibition of Candida albicans by fluvastatin is dependent on pH. Res. Lett. Biochem. vol. 2009, Article ID 151424., 2009
DeSeta F, Schmidt M, Vu B, Essmann M and Larsen B. Antifungal mechanisms supporting boric acid therapy in Candida vaginitis. J. Antimicrob. Ther. 63(2):325-336. Epub 2008 Dec 4., 2009
Schmidt M, Barker S, Essmann M and Larsen B. Effects of commonly used herbicides on the virulence factor CDR1 in Candida albicans. Environ. Toxicol. 27(11), 2346-2351., 2008
Schmidt M, Drgon T, Bowers B and Cabib E. Hyperpolarized growth of Saccharomyces cerevisiae cakP212S and cla4 mutants weakens cell walls and renders cells dependent on chitin synthase 3. FEMS Yeast Res 8(3), 362-373., 2008
Larsen B, Andersen S, Brockman A, Essmann M and Schmidt M. Key Physiological Differences in Candida albicans CDR1 Induction by Steroid Hormones and Antifungal Drugs. Yeast 23, 795-802., 2006
Schmidt M, Strenk ME, Boyer MP and Fritsch B. Importance of cell wall mannoproteins for septum formation in Saccharomyces cerevisiae. Yeast 22(9), 715-723., 2005
Schmidt M. Survival and cytokinesis of Saccharomyces cerevisiae in the absence of chitin. Microbiology 150(10), 3253-360., 2004