Marie Nguyen, Ph.D.

Additional Roles
Professor, Doctor of Osteopathic Medicine Program
Professor, Master of Science in Biomedical Sciences Program
Professor, Ph.D. in Biomedical Sciences Program

Areas of Expertise

Basic Science, Immunology, Virology

About

Teaching

My major teaching responsibilities include educating DO, DPM, DPT, and PA students in Medical Virology through leading lectures and teaching laboratories. In addition, I teach in several courses within the MSBS and PhD programs. I currently serve as director or co-director for courses within the DO, MSBS, and PhD programs.

Service

My service responsibilities are primarily fulfilled through serving on and/or chairing committees within the university and college faculty organization as well as compliance-related committees. I currently serve as chair for a university faculty organization committee. I also serve the profession through peer reviewing articles for scientific journals.

Education:
Ph.D., oncology, University of Wisconsin, 2002
B.S., biochemistry, University of Wisconsin, 1997

Research

Herpesviruses are a frequent cause of illness in otherwise healthy children and adults, and pose a significant risk for mortality in neonates and immunosuppressed populations. The diseases they cause range from skin lesions to blindness and potentially fatal encephalitis. Herpesvirus infections are uniquely challenging to treat due to their ability to cause recurrent disease, requiring long-term antiviral regimens. Currently, the viral DNA polymerase inhibitor, acyclovir, and similar compounds with the same mechanism of action, are the standard therapy for herpesvirus infections. Unfortunately, resistance to these therapies is developing in those populations that are at highest risk for severe herpesvirus disease (i.e., immunosuppressed individuals). Additionally, the currently available antivirals for herpesviruses do not eliminate the virus from latent reservoirs. Our laboratory seeks to understand how herpesviruses manipulate cellular pathways to ensure their own propagation. The goal is to use this knowledge to improve antiviral agents by interfering with these viral functions.

Publications and Presentations

Hagen, N.R., Nguyen, M.L., Williams, J.D., Bowlin, T.L., Gentry, B.G. Pentostatin antagonizes the antiviral activity of MBX-2168 by inhibiting the biosynthesis of the active compound. Antiviral Research 187: 105018. 2021.

Sauer, H.E., Nguyen, M.L., Williams, J.D., Bowlin, T.L., Gentry, B.G. Biosynthesis and Half-Life of MBX-2168-Triphosphate in Herpes Virus-Infected Cells. Antiviral Research 175: 104713. 2020.

Nguyen M.L., Gennis E., Pena K.C., Blaho J.A., Comparison of HEp-2 and Vero Cell Responses Reveal Unique Proapoptotic Activities of the Herpes Simplex Virus Type 1 α0 Gene Transcript and Product. Front Microbiol.10:998. 2019.

Pradhan P. and Nguyen, M.L. Herpes simplex virus virucidal activity of MST-312 and epigallocatechin gallate. Virus Research 249:93-98. 2018.

Haberichter, J., Roberts, S., Abbasi, I., Dedthanou P., Pradhan, P., Nguyen, M.L. The Telomerase Inhibitor MST-312 Interferes with Multiple Steps in the Herpes Simplex Virus Life Cycle. Journal of Virology. 89(19): 9804-16. 2015.

Pradhan, P., Nguyen, M.L. Early passage neonatal and adult keratinocytes are sensitive to apoptosis induced by infection with an ICP27-null mutant of herpes simplex virus 1. Apoptosis. 18: 160-70. 2013.

Cotter, CR, Kim, W., Nguyen, ML, Yount, JS, López, CB, Blaho, JA, and Moran, TM. The virion host shut-off (vhs) protein of HSV-1 blocks the replication-independent activation of NF-κB in dendritic cells. J.Virol. 85:12662-12672., 2011 – link

Nguyen, M.L. and Blaho, J.A., Telomerase Activity during Herpesvirus Infection. Future Virology. 6(8) 901-904., 2011 – link

Nguyen, M.L., Cotter, C.R., Yount, J.S., López, C.B., Blaho, J.A., and Moran, T.M., The virion host shut-off (vhs) protein blocks a TLR-independent pathway of Herpes Simplex Virus type 1 recognition in human and mouse dendritic cells. PLoS ONE. 5(2): e8684. doi:10.1371/journal.pone.0008684., 2010 – link

Nguyen, M.L. and Blaho, J.A., Cellular Players in the Herpes Simplex Virus Dependent Apoptosis Balancing Act. Viruses, 1: 965-978., 2009 – link

Nguyen, M.L., Kraft, R.M., Aubert, M., Goodwin, E., DiMaio, D., and Blaho, J.A., p53 and hTERT Determine Sensitivity to Viral Apoptosis. J.Virol. 81:12985-12995., 2007 – link

Nguyen, M.L., Kraft, R.M., and Blaho, J.A., Susceptibility of Cancer Cells to Herpes Simplex Virus Dependent Apoptosis. J. Gen. Virol.88: 1866-1875, 2007 – link

Shai, A., Nguyen, M.L., Wagstaff, J., Jiang, Y., and Lambert, P.F., HPV16 E6 Confers p53-dependent and p53-independent Phenotypes in vivo in the Absence of Functional E6AP. Oncogene 26:3321-3328, 2007 – link

Nguyen, M.L. and Blaho, J.A. Apoptosis During Herpes Simplex Virus Infection. Advances in Virus Research 69: 67-97, 2007 – link

Kraft, R.M., Nguyen, M.L., Yang, XH, Thor, A.D, and Blaho, J.A., Caspase 3 activation during herpes simplex virus 1 infection. Virus Research 120: 163-175, 2006 – link

Nguyen, M.L., Kraft, R.M., Blaho, J.A. African green monkey kidney Vero cells require de novo protein synthesis for efficient herpes simplex virus 1-dependent apoptosis. Virology 336: 274-290, 2005 – link

Schaeffer A.J., Nguyen, M.L., Liem, A., Lee, D., Montagna, C., Lambert, P.F., Ried, T., Difilippantonio, M.J. E6 and E7 Oncoproteins Induce a Distinct Pattern of Chromosomal Aneuploidy in Skin Tumors from Transgenic Mice. Cancer Research 64: 538-546, 2004 – link

Nguyen, M.N., Nguyen, M.L., Caruana, G., Bernstein, A., Lambert, P.F., Griep, A.E. Requirement of PDZ Containing Proteins for Cell Cycle Regulation and Differentiation in the Mouse Lens Epithelium. Mol. Cell. Biol. 23: 8970-8981, 2003 – link

Nguyen, M.L., Nguyen, M.N., Lee, D., Griep, A.E., and Lambert, P.F. The PDZ Ligand Domain of the Human Papillomavirus 16 E6 Protein is Required for E6’s Induction of Epithelial Hyperplasia In Vivo. J. Virol. 77: 6957-6964, 2003 – link

Nguyen, M,L. Song, S., Liem, A, Liu, Y, Androphy, E., Lambert, P.F. A Mutant of Human Papillomavirus Type 16 Deficient in Binding a-Helix Partners Mediate the Oncogenic Potential in vivo. J. Virol. 76:13039-13048, 2002 – link

Awards and Honors

Marie Nguyen, Ph.D.

Teaching

Service

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