515-271-1626 (Office Phone)
Areas of Expertise
My laboratory utilizes a variety of biochemical and physiological approaches in both tissue culture and genetically modified mouse model systems to study how G protein-coupled receptors (GPCRs) can be targeted to treat myocardial inflammation, atherosclerosis, and hypertension. We are particularly interested in determining the role that GPCR signaling plays in the regulation of autophagy in cardiac myocytes, macrophages, and other cell types. Autophagy is a highly regulated process by which unnecessary or damaged proteins, organelles, and other cytoplasmic components are delivered to the lysosome where they are degraded and recycled to maintain cellular homeostasis. Our long-term goal is to discover therapeutic interventions targeting GPCRs.
|Postdoctoral Training, University of Texas Southwestern Medical Center, Department of Pharmacology|
|Ph.D., Pharmacology, University of North Carolina at Chapel Hill|
|B.S., Biology, Creighton University|