Jun Dai, M.D., M.Sc., Ph.D.

Publications in peer-reviewed journals (selected in chronological order)

*Corresponding author, ** Co-first author

1. Dai J*, Leung M, Guan W, Guo H-T, Krasnow RE, Wang TJ, El‐Rifai W, Zhao Z, Reed T. Whole-Genome Differentially Hydroxymethylated DNA Regions among Twins Discordant for Cardiovascular Death. Genes (Basel). 2021, 12(8), 1183-1202. https://doi.org/10.3390/genes12081183
2. Wu S-H, Ozaki K, Krasnow RE, Reed T, Dai J*. A new look at genetic and environmental architecture on lipids using non-normal structural equation modeling in male twins: The NHLBI Twin Study. Behav Genet. 2017 Jul;47(4):425-433. doi: 10.1007/s10519-017-9841-7. Epub 2017 Apr 17.
3. Dai J*, Krasnow RE, Reed T. Midlife Moderation-Quantified Healthy Diet and 40-year Mortality Risk from Coronary Heart Disease: The Prospective NHLBI Twin Study. Br J Nutr. 2016 Jul;116(2):326-34. doi: 10.1017/S0007114516001914. Epub 2016 May 18.4.       Dai J*, Mukamal KJ, Krasnow RE, Swan GE, Reed T. Higher usual alcohol consumption was associated with a lower 41-y mortality risk from coronary artery disease in men independent of genetic and common environmental factors: the prospective NHLBI Twin Study. Am J Clin Nutr. 2015;102(1):31-9. doi: 10.3945/ajcn.114.106435. Epub 2015 May 6. (Honored as Editor’s Pick for Volume 102 Issue 1 of Am J Clin Nutr)
4. Dai J*, Jones DP, Goldberg J, Ziegler TR, Bostick RM, Wilson PW, Manatunga AK, Shallenberger L, Jones L, Vaccarino V. Association between adherence to the Mediterranean diet and oxidative stress. Am J Clin Nutr. 2008;88(5):1364-70
5. Dai J, Miller AH, Bremner D, Goldberg J, Jones L, Buckham R, Murrah N, Veledar E, Wilson PW, Vaccarino V. Adherence to the Mediterranean diet is inversely associated with circulating interleukin-6 among middle-aged males: a twin study. Circulation. 2008; 117(2):169-75
6. Dai J*, Su Y, Xu Y. [Active research can improve the development of self-teaching, scientific thinking and practicing for medical students.] China Advanced Medical Education Development. 2000;277-82.
7. Su Y, Dai J, Mei J. [Presentation – a way to enhance the confidence and the communication skill of medical students.] Academic J of Sun Yat-sen University of Medical Sciences (Social Sciences). 2001;4:110-1 3.
8. Dai J*, Su Y, Xu Y, Jiang Z. [Transferring the new development in nutrition into medical education.] Academic J of Sun Yat-sen University of Medical Sciences (Social Sciences). 2001;4:129-31 4.
9. Wang Z-Q**, Dai J**, Liang P-R, Liu Z. [Effects of nutritional education in pregnant women on the neonatal health.] Chinese Journal of Eugenics & Heredity. 1994;2(3):38-40  (*co-first authors)
10. Ma J, He M, Mei J, Chen Q, Jiang Z, Dai J, Luo Y, Lui SS, Anderson GH, Ho Z-Q. [The health status of 1152 infants and the influence factors.] Maternal & Child Health Care of China. 1995; 10(4):230-31.
11. Dai J*, He M, Mei J, Chen Q, Jiang Z, Ma J, Lui SS, Anderson GH, Ho Z-Q. [Breast-feeding patterns and development of 4-month old infants in Guangdong province.] Maternal & Child Health Care of Guangdong. 1996;2(3):1-4.
12. Dai J*, Su Y. [Dietary fatty acids, blood lipids, and atherosclerosis.] Chinese J Public Health. 1998;14(8): 494-7.
13. Dai J*, Su Y, Ling W, Liang Y, Zhong C, Ou X. [Study of fatty acids composition ratio of oral fat loads used in postprandial lipids and lipoproteins metabolism.] Chinese J Arteriosclerosis. 2000;8(3):8-13
14. Dai J*, Su Y, Yan F, Liu S, Xu L, Li J. [The pattern of diet and dietary fatty acids in type 2 diabetic out-patients investigated with an accurate food frequency method.] Chinese J Public Health. 2000;16(1):43-4
15. Dai J*, Su Y, Ling W, Liang Y, Zhong C, Gao L. [Recommendation of dietary fatty acid composition ratios for type 2 diabetic patients.] Acta Nutrimenta Sinica. 2000;22(3):256-60
16. He M, Mei J, Jiang Z, Chen Q, Ma J, Dai J, Li M, Su Y, Lui SS, Yeung DL, Anderson GH. Growth of infants during the first 18 months of life in urban and rural areas of southern China. J Paediatr Child Health. 2001;37(5):456-64
17. He M, Ma J, Chen Q, Mei J, Dai J, Luo Y, Jiang Z, Lui SS, He Z, Yeung DL, Anderson GH. Growth and feed practices of 4 and 8 months infants in Southern China. Nutrition Research. 2001;21(1):103-20
18. Shen HM, Dai J, Chia SE, Lim A, Ong CN. Detection of apoptotic alterations in sperm in subfertile patients and their correlations with sperm quality. Hum Reprod. 2002;17(5):1266-73
19. Dai J*, Su Y, Ling W, Liang Y, Zhong C. [Effects of dietary fatty acid composition ratios on the postprandial metabolism of plasma triglycerides.] Chinese J Arteriosclerosis. 2002;10(2):144-8
20. Dai J*, Ling W, Su Y, Gao L, Zhuo S. [Effects of dietary fatty acid composition ratios on the development of atherosclerosis in New-Zealand Rabbits.] Acta Nutrimenta Sinica. 2003,25(1):25-8
21. Gregory CO, Dai J, Ramirez-Zea M, Stein AD. Occupation is more important than rural or urban residence in explaining the prevalence of metabolic and cardiovascular disease risk in Guatemalan adults. J Nutr. 2007;137(5):1314-9
22. Su S, Snieder H, Miller AH, Ritchie J, Bremner JD, Goldberg J, Dai J, Jones L, Murrah NV, Zhao J, Vaccarino V. Genetic and environmental influences on systemic markers of inflammation in middle-aged male twins. Atherosclerosis. 2008;200(1):213-20
23. Dai J, Miller AH, Bremner D, Goldberg J, Jones L, Buckham R, Murrah N, Veledar E, Wilson PW, Vaccarino V. Adherence to the Mediterranean diet is inversely associated with circulating interleukin-6 among middle-aged males: a twin study. Circulation. 2008; 117(2):169-75
24. Vaccarino V, Brennan M-L, Miller AH, Bremner JD, Ritchie JC, Lindau F, Veledar E, Su S, Murrah NV, Jones L, Jawed F, Dai J, Goldberg J, Hazen SL. Association between major depressive disorder and serum myeloperoxidase and other markers of inflammation: A Twin Study. Biol Psychiatry. 2008;64(6):476-83
25. Dai J*, Jones DP, Goldberg J, Ziegler TR, Bostick RM, Wilson PW, Manatunga AK, Shallenberger L, Jones L, Vaccarino V. Association between adherence to the Mediterranean diet and oxidative stress. Am J Clin Nutr. 2008;88(5):1364-70
26. Dai J*, Su Y, Bartell S, Le N-A, Ling W, Liang Y, Gao L, Wu H, Veledar E, Vaccarino V. Beneficial effects of designed dietary fatty acid compositions on lipids in triacylglycerol-rich lipoproteins among Chinese type 2 diabetic patients. Metabolism-Clinical and Experimental. 2009;58(4):510-518
27. Dai J*, Ziegler TR, Bostick RM, Manatunga AK, Jones DP, Goldberg J, Wilson PW, Jones L, Shallenberger L, Vaccarino V. High habitual dietary alpha-linolenic acid intake is associated with decreased plasma soluble interleukin-6 receptor concentrations among male twins. Am J Clin Nutr. 2010 Jul;92(1):177-85. Epub 2010 May 12.
28. Dai J*, Lampert R, Wilson PW, Goldberg J, Ziegler T, Vaccarino V. Mediterranean dietary pattern is associated with improved cardiac autonomic function among middle-aged men: A twin study. Circ Cardiovasc Qual Outcomes. 2010 Jul;3(4):366-73. Epub 2010 Jun 15.
29. Ferranti EP, Dunbar SB, Higgins M, Dai J, Ziegler TR, Frediani JK, Reilly C, Brigham KL. Psychosocial factors associated with diet quality in a working adult population. Res Nurs Health. 2013;36(3):242-56.
30. Dai J*, Krasnow RE, Liu L, Sawada SG, Reed T. The association between postload plasma glucose levels and 38-Year mortality risk of coronary heart disease: the prospective NHLBI Twin Study. PLOS One. 2013;8(7): e69332. doi:10.1371/journal.pone.0069332
31. Wu S-H, Neale MC, Acton AJ Jr, Considine RV, Krasnow RE, Reed T, Dai J*. Genetic and environmental influences on the prospective correlation between systemic inflammation and coronary heart disease death in male twins. Arterioscler Thromb Vasc Biol. 2014 Sep;34(9):2168-74. doi: 10.1161/ATVBAHA.114.303556. Epub 2014 Jul 31.
32. Wu S-H, Guo Q, Viken RJ, Reed T, Dai J*. Heritability of usual alcohol hangover and intoxication in male twins: the NAS-NRC Twin Registry. Alcohol Clin Exp Res. 2014 Aug;38(8):2307-13. doi: 10.1111/acer.12487.
33. Dai J*, Mukamal KJ, Krasnow RE, Swan GE, Reed T. Higher usual alcohol consumption was associated with a lower 41-y mortality risk from coronary artery disease in men independent of genetic and common environmental factors: the prospective NHLBI Twin Study. Am J Clin Nutr. 2015;102(1):31-9. doi: 10.3945/ajcn.114.106435. Epub 2015 May 6. (Honored as Editor’s Pick for Volume 102 Issue 1 of Am J Clin Nutr)
34. Dai J*, Krasnow RE, Reed T. Midlife Moderation-Quantified Healthy Diet and 40-year Mortality Risk from Coronary Heart Disease: the Prospective NHLBI Twin Study. Br J Nutr. 2016 Jul;116(2):326-34. doi: 10.1017/S0007114516001914. Epub 2016 May 18.
35. Wu S-H, Kim T-K, Wu X, Scherler K, Baxter D, Wang K, Krasnow RE, Reed T, Dai J*. Circulating microRNAs and life expectancy among identical twins. Ann Hum Genet. 2016 Jul 12. doi: 10.1111/ahg.12160.
36. Wu S-H, Ozaki K, Krasnow RE, Reed T, Dai J*. A new look at genetic and environmental architecture on lipids using non-normal structural equation modeling in male twins: The NHLBI Twin Study. Behav Genet. 2017 Jul;47(4):425-433. doi: 10.1007/s10519-017-9841-7. Epub 2017 Apr 17.
37. Yao Y, Chen S-B, Ding G, Dai J*. Evaluation of Reliability of the Recomputed Nutrient Intake Data in the National Heart, Lung, and Blood Institute Twin Study. Nutrients 2019 Jan 8;11(1), 109. pii:E109. doi:10.3390/nu11010109.

Manuscripts in progress (*Corresponding author)

• Dai J*, Ferguson J. Association between genetic risk score for glucose hemostasis and coronary heart disease from electronic medical records and genotyping data in the hospital-based patient population

Selected book chapters

• Dai J. Clinical nutrition support in otolaryngological trauma. In: Su Z-F, ed. Otolaryngological Trauma. 1^st ed. Beijing, PR China: People’s Medical Publishing House; 2004
• Dai J. How to add weaning foods? In: What food will improve the health of infants and children?
  Xi-An Publishing House. Xi-An, PR China. 1998

Invited Speaker (Selected)

• “Mediterranean Diet, Biomarkers, Vascular and Neural Disease”, presented at the 7^th International Stroke Summit, Nanjing, Jiangsu, China, July 8-11, 2011 (presented as Keynote speaker)
• “Diet for Heart Disease Prevention and Treatment”. Presented at the American Association of Clinical Endocrinologists and the American Society for Nutrition Joint Meeting on Nutrition 2010 “Therapeutic Diets for Cardiometabolic Disorders: What is the Evidence”?, Boston, MA, April 21, 2010.
• “Introduction on the study of ‘Protective mechanisms of the Mediterranean diet: A Twin Study’”. Presented to the staff of Southeast American Heart Association and donors, Emory School of Medicine, Atlanta, GA, the US, March 2007
• “Enteral and parenteral nutrition”. Presented to physicians, nutritionists, and dietitians at the Advanced Training Program in Clinical Nutrition, Guangzhou, Guangdong, PR China, 2002
• “Nutritional therapy for infectious disease”. Presented to nutritional physicians, nutritionists and dietitians at the Advanced Training Program in Clinical Nutrition, Guangzhou, Guangdong, PR China, 2002

Abstracts and Presentations

Published peer-reviewed abstracts (in chronological order)

• Dai J, Ramirez-Zea M, Gregory C, Stein AD. Rural to urban migration and metabolic syndrome in Guatemala. Proceedings from FASEB/Experimental Biology Symposium 2005, San Diego, California, Apr 2-6, 2005 (Abstract Number 274.4)
• Dai J, Miller AH, Bremner JD, Goldberg J, Jones L, Buckham R, Murrah N, Vaccarino V. Adherence to the Mediterranean diet decreases systemic IL-6 among middle-aged monozygotic male twins free of symptomatic cardiovascular disease. Circulation. 2006;114(18):II-883
• Dai J, Miller AH, Brenner JD, Goldberg J, Jones L, Jovonee F, Buckham R, Murrah N, Veledar E, Vaccarino V. Shared Genetic and Environmental Factors Do Not Confound the Association Between Adherence to the Mediterranean Diet and Inflammation. Circulation. 2007;115(8):e218
• Dai J, Jones DP, Goldberg J, Bostick BM, Ziegler TR, Wilson PW, Shallenberger L, Jones L, Vaccarino V. Shared Genetic and Environmental Factors Do Not Confound the Association Between Adherence to the Mediterranean Diet and Oxidative Stress. Circulation. 2008;117(11):e207
• Dai J, Lampert R, Wilson PW, Goldberg J, Ziegler TR, Vaccarino V. Adherence to the Mediterranean diet is associated with improved cardiac autonomic function among middle-aged men. Circulation. 2009;119(10):e294
• Dai J, Krasnow RE, Reed T. Common Environment Links Post-Load Plasma Glucose Levels to Coronary Heart Disease Death Risk in Men: the National Heart, Lung, and Blood Institute Twin Study. Final Program and Abstract of Joint Conference on Cardiovascular Epidemiology and Prevention; Nutrition, Physical Activity and Metabolism. 2010:37.
• Dai J, Krasnow RE, Reed T. Usual Alcohol Consumption Is Inversely Associated With a 38-Year Coronary Heart Disease Death Risk Independent of Genes and Common Environment among Men. Final Program and Abstract of the 51th American Heart Association Scientific Session on Joint Conference on Cardiovascular Epidemiology and Prevention; Nutrition, Metabolism, and Physical Activity. Mar 22-29, 2011, Atlanta, GA.
• Dai J, Acton JA, Considine RV, Krasnow RE, Reed T. Systemic Inflammation Does Not Mediate the Inverse Association between Usual Alcohol Consumption and a 39-Year Death Risk from Incident Coronary Heart Disease Independent of Genes and Common Environment among Men. Final Program and Abstract of the 52th American Heart Association Scientific Session on Joint Conference on Cardiovascular Epidemiology and Prevention; Nutrition, Metabolism, and Physical Activity. Mar 13-16, 2012, San Diego, CA
• Dai J, Leung M, Krasnow R, Reed T and El-Rifai W. Whole-genome DNA hydroxymethylation among monozygotic twins discordant for cardiovascular death: the prospective National Heart, Lung, and Blood Institute (NHLBI) Twin Study. FASEB J. 2018 April;32(1_supplement):755.5.
• Mukherji P, Leung M, El-Rifai W, Krasnow R, Reed T, Dai J*. Methylation levels at growth differentiation factor-15 related CpG sites are not related to death risk from cardiovascular disease among monozygotic male twins discordant for cardiovascular disease: National Heart, Lung, And Blood Institute Twin Study. American Heart Association Epidemiology/Lifestyle Scientific Session; 2018 March 20-23; New Orleans, Louisiana, USA.

Peer-reviewed presentations

Oral Presentations

1. Dai J, Miller AH, Bremner D, Goldberg J, Jones L, Foster  J, Buckham J, Murrah N, Vaccarino V. Adherence to the Mediterranean Diet Decreases Systemic IL-6 among Middle-aged Monozygotic Male Twins Free of Symptomatic Cardiovascular Diseases. American Heart Association Scientific Sessions 2006, Chicago, IL, the US, Nov 12-16, 2006 (Abstract No. 13758 & Presentation No. 4095)
2. Dai J, Miller AH, Bremner D, Goldberg J, Jones L, Buckham R, Murrah N, Veledar E, Vaccarino V. Shared Environmental and Genetic Effects Do Not Confound the Association between the Mediterranean Diet and Inflammation. 47^th AHA Conference on Cardiovascular Disease Epidemiology and Prevention and Nutrition, Physical Activity and Metabolism, Orlando, FL, the US, Feb 28-Mar 3, 2007 (Abstract No. 400 & Presentation No. 14)
3. Dai J, Jones DP, Goldberg J, Ziegler TR, Bostick RM, Wilson PW, Manatunga AK, Shallenberger L, Jones L, Vaccarino V. Shared Genetic and Environmental Factors Do Not Confound the Association between Adherence to the Mediterranean Diet and Oxidative Stress. 48^th AHA Conference on Cardiovascular Disease Epidemiology and Prevention and Nutrition, Physical Activity and Metabolism, Colorado Springs, Colorado, March 11 –15, 2008 (Abstract No. 456 & Presentation No. 38)
4. Gottumukkala P, Leung M, Steffen L, Jacobs Jr D, Dai J*. Mediterranean Diet Pattern in the Multi-Ethnic Study of Atherosclerosis (MESA). Des Moines University Summer Mentored Student Research Closing Program, Des Moines, IA, July 21, 2017
5. Mukherji P, Leung M, El-Rifai W, Krasnow R, Reed T, Dai J*. Methylation levels at growth differentiation factor-15 related CpG sites are not related to death risk from cardiovascular disease among monozygotic male twins discordant for cardiovascular disease: National Heart, Lung, And Blood Institute Twin Study. Des Moines University Research Symposium, Des Moines, IA, December 6, 2017 (Best Oral Presentation Award)1.    Stein AD, Dai J, Gregory C, Ramirez-Zea M. The nutrition transition in Guatemala: Rural to urban migration, lifestyle, and the metabolic syndrome. The XVII IEA World Congress of Epidemiology (WCE 2005). Bangkok, Thailand, Aug 21-25, 2005 (Abstract No.10370)
6. Andrade JG and Dai J*. Genetic Factors have less Influence on Obesity in Adult Male Twins – the longitudinal National Heart, Lung, and Blood Institute Twin Study. Des Moines University Summer Mentored Student Research (MSRP) Closing Program, Des Moines, IA, July 19, 2019 (Oral Lightning Presentation)

Moderated Poster Presentations

• Dai J, Krasnow RE, Reed T. Usual Alcohol Consumption Is Inversely Associated With a 38-Year Coronary Heart Disease Death Risk Independent of Genes and Common Environment among Men. Final Program and Abstract of the 51th American Heart Association Scientific Session on Joint Conference on Cardiovascular Epidemiology and Prevention; Nutrition, Metabolism, and Physical Activity. Mar 22-29, 2011, Atlanta, GA.

Honored Poster Presentations

• Dai J, Krasnow RE, Reed T. Usual Alcohol Consumption Is Inversely Associated With a 38-Year Coronary Heart Disease Death Risk Independent of Genes and Common Environment among Men. The American Heart Association Scientific Session 2011. Fall 14-16, 2011, Orlando, FL (Honored as the best presentation at the AHA Specialty Conferences 2011).

Poster Presentations

1. Dai J, Ramirez-Zea M, Gregory C, Stein AD. Rural to urban migration and metabolic syndrome in Guatemala. FASEB/Experimental Biology 05, San Diego, California, Apr 2-6, 2005 (Program Number: 274.4)
2. Dai J, Lampert R, Wilson PW, Goldberg J, Ziegler TR, Vaccarino V. Adherence to the Mediterranean Diet Is Associated With Improved Cardiac Autonomic Function among Middle-Aged Men.  49^th AHA Conference on Cardiovascular Disease Epidemiology and Prevention and Nutrition, Physical Activity and Metabolism, Colorado Springs, Palm Harbor, Florida, March 10 –14, 2009 (Abstract No. 173 & Presentation No. P49) 
3. Dai J, Krasnow RE, Reed T. Common Environment Links Post-Load Plasma Glucose Levels to Coronary Heart Disease Death Risk in Men: the National Heart, Lung, and Blood Institute Twin Study. 50^th AHA Conference on Cardiovascular Disease Epidemiology and Prevention and Nutrition, Physical Activity and Metabolism, San Francisco, CA, March 2–5, 2010 (Abstract No. 20 & Presentation No. P112)
4. Dai J, Acton JA, Considine RV, Krasnow RE, Reed T. Systemic Inflammation Does Not Mediate the Inverse Association between Usual Alcohol Consumption and a 39-Year Death Risk from Incident Coronary Heart Disease Independent of Genes and Common Environment among Men. Final Program and Abstract of the 52th American Heart Association Scientific Session on Joint Conference on Cardiovascular Epidemiology and Prevention; Nutrition, Metabolism, and Physical Activity. Mar 13-16, 2012, San Diego, CA
5. Dai J, Acton JA, Considine RV, Krasnow RE, Reed T. Influence of Systemic Interleukin-6 on the Inverse Association between Your-Choice American Heart Diet and a 41-Year Mortality Risk from Coronary Heart Disease among Men. Final Program and Abstract of the 54th American Heart Association Scientific Session on Joint Conference on Cardiovascular Epidemiology and Prevention; Nutrition, Metabolism, and Physical Activity. Mar 18-21, 2014, San Francisco, CA
6. Dai J, Leung M, Krasnow R, Reed T and El-Rifai W. Whole-genome DNA hydroxymethylation among monozygotic twins discordant for cardiovascular death: the prospective National Heart, Lung, and Blood Institute (NHLBI) Twin Study. Experimental Biology (EB) 2018. Apr 21-25, 2018, San Diego, CA
7. Mukherji P, Leung M, El-Rifai W, Krasnow R, Reed T, Dai J*. Methylation levels at growth differentiation factor-15 related CpG sites are not related to death risk from cardiovascular disease among monozygotic male twins discordant for cardiovascular disease: National Heart, Lung, And Blood Institute Twin Study. American Heart Association Epidemiology/Lifestyle Scientific Session; March 20-23, 2018, New Orleans, Louisiana, USA (Poster Presentation: P055). (*corresponding author)
8. Krone A, Reed T, Dai J*. Genetic Influences on Obesity in Male Twins – the National Heart, Lung, and Blood Institute Twin Study. Des Moines University Summer Mentored Student Research (MSRP) Closing Program, Des Moines, IA, July 18, 2016
9. Gottumukkala P, Leung M, Dai W, Steffen L, Jacobs Jr D, Dai J*. Influence of variation in dietary score elements and dichotomization cutoffs of the elements on Mediterranean Dietary Score in the Multi-Ethnic Study of Atherosclerosis (MESA). Des Moines University Summer Mentored Student Research (MSRP) Closing Program, Des Moines, IA, July 20, 2018
10. Gottumukkala P, Leung M, Steffen L, Jacobs Jr D, Dai J*. Negative association between adherence to alternative moderation-quantified healthy diet and incident coronary heart disease in the prospective Multi-Ethnic Study of Atherosclerosis (MESA). Des Moines University Research Symposium, Des Moines, IA, December 6, 2018
11. Strandlund S, Leung M, Gottumukkala P, Kim T-Y, Wang K, Wu X, Baxter D, Steffen L, Jacobs Jr D, Ballantyne CM, Gupta DK, Dai J*. Gender and racial differences in circulating extracellular microRNAs in participants without cardiovascular disease or diabetes: Atherosclerosis Risk in Communities (ARIC) Study. Des Moines University Research Symposium, Des Moines, IA, December 6, 2018
12. Joseph G Andrade and Dai J*. Genetic Factors have less Influence on Obesity in Adult Male Twins – the longitudinal National Heart, Lung, and Blood Institute Twin Study. Des Moines University Summer Mentored Student Research (MSRP) Closing Program, Des Moines, IA, July 19, 2019 (Poster Presentation: 24)