Applying an established therapy to a new disease

Des Moines University Clinic Health Topics: What is Coronavirus?

Two of the many challenges that the coronavirus thrust upon frontline medical providers were having to treat very sick patients for a disease the providers were largely learning about in real time, and facing risks to their own health in doing so. Those realities prompted Matthew Trump, D.O.โ€™08, FACP, FCCP, and his colleagues across UnityPoint Health-Des Moines (UPH-DM) to try a novel treatment for some COVID-19 patientsโ€™ hypoxia โ€“ using high-flow nasal cannula (HFNC) rather than mechanical ventilation.

That approach is less invasive, has fewer complications and can provide some patients with enough breathing support to recover. Unlike being on a ventilator, patients who are being treated with HFNC are able to eat, talk and walk on their own.

โ€œEarly on, during the surge of cases in New York, there was a lot of talk about treating patients with intubation and ventilators,โ€ says Trump, a pulmonary and critical care physician with the Iowa Clinic, which works with UPH-DM. โ€œThere were reports of hospitals filling up with patients quickly and getting overwhelmed. We knew we had to start planning.โ€

HFNC therapy, which delivers oxygen and water vapor through a tube in the nose, is not new, but applying it to a new disease was. That required countless meetings among โ€œanybody taking care of patients,โ€ Trump says, to assess data, prepare protocols and mobilize resources.

Their efforts reaped benefits: As of mid-May, UPHDM had treated 73 percent of its critically ill COVID-19 patients without ventilators. The total intubation rate of all the COVID-19 patients across UPH-DMโ€™s five hospitals was 10 percent.

Other benefits: HFNC doesnโ€™t expose providers to disease-spreading droplets from patientsโ€™ airways the way intubation can, and the therapy can be applied to patients outside of intensive care.

โ€œWe were able to manage more than half our COVID-19 patients outside the ICU, keep the ICU up and running for other surgically critical patients and preserve ICU resources,โ€ Trump says. โ€œThat allowed the hospitals to get patients who didnโ€™t have coronavirus the care they needed.โ€

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