The topic for this weeks Friday Seminar Series will be physiology and pharmacology. All faculty members and students are invited to attend.
Signaling through the Calmodulin Interactome
Dr. Persechini indicated he has no financial relationships to disclose relevant to the content of this CME activity.
- Explain the role of calmodulin in cell signaling.
- Appreciate the complexity of the calmodulin interactome and its responses.
Disturbances in cell signaling are associated with many clinical disorders, including cancer, Altzheimer’s, arthritis, chronic pain syndrome, cardiac arrythmias and hypertension. Ca2+ ion is a universal intracellular signaling molecule, and the Ca2+-binding protein calmodulin plays a central role in converting Ca2+ signals into the biochemical changes needed to produce the desired cellular response. Our work is focused on both the cell biology and biochemistry of this process. An ongoing interest is in defining the thermodynamic and kinetic mechanisms that govern the interactions between calmodulin and its many protein targets. More recently we have begun investigations of calmodulin function using genetically-encoded fluorescent indicator proteins developed in our laboratory. These tools allow us to follow calmodulin-dependent signaling using imaging techniques, with the ultimate goal of developing a mechanistic understanding of how calmodulin controls and coordinates the activities of its many targets in living cells.
AOA: Des Moines University and the AOA Council on Continuing Medical Education approve this program for a maximum of 1.0 hour of AOA Category 2-A CME credits.
Other: Attendees will receive 1.0 hour of continuing education contact hours.
Educational grants are not being accepted for this activity.
Everyone in a position to control the content of this educational activity will disclose to the CME provider and to attendees all relevant financial relationships with any commercial interest. They will also disclose if any pharmaceuticals or medical procedures and devices discussed are investigational or unapproved for use by the U.S. Food and Drug Administration (FDA). Determination of educational content for this program and the selection of speakers are responsibilities of the program director. Firms providing financial support did not have input in these areas.
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