Investigation of Statin Actions on Signal Transduction Pathways in an Aggressive Natural Killer Cell Leukemia Cell Lines
- Differentiate between cases of natural killer cell leukemia, their symptoms, and prognosis when compared to other lymphomas.
- Describe previous research involving statins as a tool in cancer treatment.
- Analyze and question the mechanisms by which statins act on signal transduction pathways in NK cell leukemia.
- Have an ability to interpret a human Phospho-MAPK array.
Identification and Characterization of Calmodulin-Binding Domains in the Angiotensin II Receptor 1A
- Identify how FRET based biosensors offer an exhaustive approach to identify potential calmodulin binding domains of the angiotensin II receptor 1A (AT1R).
- Demonstrate how our methods, in combination with FRET based biosensors and suitable Ca2+ indicators, allows precise assessment of the Ca2+ sensitivity between CaM and its partners, which is useful in predicting physiological function.
Kevin Ehlers, MBS’17
Ashley Yingst, MBS’17
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