Characterization of a Novel Molecular Pathway in Autoimmunity
Manuel Galvan, Ph.D.
Researcher, Des Moines University
Dr. Galvan recently started at Des Moines University working with Dr. Suzanne Bohlson. Their laboratory focuses on phagocyte recognition and clearance events with the goal of developing therapies that strengthen the body’s ability to ingest and kill infectious particles or dead/dying cells. Specific cells in the body are designed to ingest dangerous particles, such as invading bacteria. These professional eating cells, or phagocytes, also eat dead or dying cells. This process of clearance of dead or dying cells is necessary to allow for the repair of damaged tissue, and to maintain normal tissue. When this process of cellular ingestion (phagocytosis) is dysregulated, the body becomes susceptible to chronic infections and autoimmunity.
- Comprehend the role of macrophages in apoptotic cell clearance.
- Comprehend why lack of apoptotic cell clearance leads to autoimmunity.
- Asses apoptotic cell clearance using in-vitro assays.
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