The objective of our studies is to understand the role of phospholipase during restenosis  Our studies implicate that cPLA2 is involved two major processes in the development of restenosis.  We are performing studies looking at smooth muscle migration and proliferation in cells that have been either inhibited or deficient in cPLA2.  We are measuring the amount of macrophage inflammation that effects smooth muscle cells proliferation and intimal hyperplasia during restenosis in the femoral artery of mice deficient in cPLA2. We hypothesize that cPLA2 is a key component in the chemotaxis of macrophages which drives the inflammatory process in restenosis as well as being needed for smooth muscle cell proliferation.