James Lang

Lang, James (2)
Position(s)
Assistant Professor Doctor of Physical Therapy
Master of Science in Biomedical Sciences
Office Phone 515-271-1733
Email james.lang@dmu.edu
Education
  • Postdoctoral Fellow, University of Missouri – Columbia
  • Ph.D. in Kinesiology, The Pennsylvania State University, University Park, PA
  • Masters in Exercise Science, University of Iowa, Iowa City, IA
  • Bachelors in Exercise Science, University of Iowa, Iowa City, IA

Area of Expertise Exercise physiology with an emphasis in cardiovascular and environmental physiology
Professional Organizations, Committees and Boards
  • American Physiological Society
    Exercise and Environmental Physiology and Cardiovascular Sections
  • American College of Sports Medicine
    Basic Science Affiliation
Service Professional:

  • Journal Review Activities
    • Annals of Biomedical Engineering
    • Journal of Applied Physiology
    • Recent Patents on Cardiovascular Drug Discovery
    • American Journal of Physiology
    • Medical Science Monitor
    • International Journal of Sport Medicine

Awards and honors

  • 2010 Predoctoral Research Recognition Award, Environmental and Exercise Physiology Section, American Physiological Society
  • 2009 Environmental Graduate Student Research Award, American College of Sports Medicine
  • 2009 Caroline tum Suden /Francis Hellebrandt Professional Opportunity Award, American Physiological Society
  • 2009 Professional Skills Training Course (“Writing and Reviewing for Scientific Journals”) in Orlando, FL, American Physiological Society

Currently, the direction of my lab is to examine peripheral autonomic and microvascular function in humans.  This area of research utilizes an in vivo approach to investigate the mechanisms of how cutaneous vessels respond to local or whole-body thermal stimuli.  The utility of measuring vascular reactivity in the skin extends to 1) understanding thermoregulatory mechanisms, 2) an accessible means of studying general microvascular function, and 3) a prognostic indicator of cardiovascular disease since alterations in microvasculature function often precedes more systemic impairment with cardiovascular disease states.

Grant Activity

Research Support (Grants funded)

  • Iowa Osteopathic and Education Research Funds; Des Moines University “Role of Noradrenergic and Cotransmitter Mechanisms of Adrenergic Responsiveness to Sympathoexcitation in Young and Older Adults” Amount:  $24,963
  • Iowa Osteopathic and Education Research Funds; Des Moines University “The Role of Angiotensin II in the Cutaneous Vasoconstrictor Response” Amount: $19,768
  • Research start-up package; Des Moines University Amount: $75,000
  • Center for Scholarly and Creative Excellence; Grand Valley State University “Influence of L-tyrosine on the Human Pressor Response to Sympathetic Activation” Amount: $3000
  • Pew Technology Enhancement Grant (#12-235); Grand Valley State University “Utilization of Data Acquisition Systems to Enhance Student Lab Experiences” Amount: $3000
  • Research start-up package; Grand Valley State University Amount: $20,000
  • T32 NIH Training Grant (T32 AR 048532-06); University of Missouri “Exercise and Health: Integration from Molecule to Patient” Amount:  $37,740 Role:  Postdoctoral Fellow
  • Carl V. Gisolfi Memorial Research Grant; American College of Sports Medicine “The Effects of Aging on the Vasoconstrictor Response to Whole-Body Cooling in Human Skin” Amount: $5000 Role:  PI

Publications

Lambert, G.P., Lang, J., Welch, R., Lanspa, S. Effect of L-arginine absorption of a glucose-electrolyte solution in humans. J Exercise Physiol Online. 14(4): 75-86, 2011

Simmons, G.H., Padilla J., Young, C.N., Wong, B.J., Lang, J.A., Davis, M.J., Laughlin, M.H., and P.J. Fadel. Increased brachial artery retrograde shear rate at exercise onset is abolished during prolonged cycling: role of thermoregulatory vasodilation. J Appl Physiol. 110(2): 389-397, 2011

Lang, J.A., Holowatz, L.A. and W.L. Kenney. Tetrahydrobiopterin does not affect end-organ responsiveness to norepinephrine-mediated vasoconstriction in aged skin. Am J Physiol Regul. 299(6): R1651-1655, 2010

Holowatz, L.A., Jennings, J.D., Lang, J.A., and W.L. Kenney. Systemic low-dose aspirin and clopidogrel independently attenuate reflex cutaneous vasodilation in middle-aged humans. J Appl Physiol. 108(6): 1575-1581, 2010

Lang, J.A., Holowatz, L.A. and W.L. Kenney. Local tyrosine or tetrahydrobiopterin supplementation corrects the age-related decline in cutaneous vasoconstriction. J Physiol. 588(8): 1361-1368, 2010

Lang, J.A., Jennings, J.D., Holowatz, L.A. and W.L. Kenney. Reflex vasoconstriction in aged human skin increasingly relies on rho-kinase dependent mechanisms during whole-body cooling. Am J Physiol Heart Circ Physiol. 297(5): H1792-H1797, 2009

Holowatz, L.A., Jennings, J.D., Lang, J.A., and W.L. Kenney. Ketorolac alters blood flow during normothermia but not during hyperthermia in middle-aged human skin. J Appl Physiol. 107(4): 1121-1127, 2009

Lang, J.A., Holowatz, L.A. and W.L. Kenney. Local tetrahydrobiopterin administration augments cutaneous vasoconstriction in aged human skin. J Physiol. 587: 3967-74, 2009

Baker, L.B., Lang, J.A., and W.L. Kenney. Change in body mass accurately and reliably predicts change in body water. Eur J Appl Physiol. 105(6): 959-967, 2009

Lambert G.P., Lang J., Bull A, Eckerson J, Lanspa S, O’Brien J. Fluid tolerance while running: effect of repeated trials. Int J Sports Med. 29(11): 878-882, 2008

Baker, L.B., Lang, J.A., and W.L. Kenney. Quantitative analysis of the serum sodium concentration after prolonged running in the heat. J Appl Physiol. 105(1): 91-99, 2008

Lambert G.P., Lang J., Bull A, Pfeifer P.C., Eckerson J, Moore G, Lanspa S, O’Brien J. Fluid restriction during running increases GI permeability. Int J Sports Med. 29(3):194-198, 2008

Lang J.A., Gisolfi C.V., and G. P. Lambert. Effect of exercise intensity on active and passive glucose absorption. Int J Sport Nutr Exerc Metab. 16(5): 485-493, 2006